podophyllotoxin - HEALTHY
Please provide your email address to receive an email when new articles are posted on . No association was found between exposure to podophyllotoxin during pregnancy and adverse fetal outcomes, ... The Himalayan mayapple is an endangered plant species but humans need it because it naturally produces podophyllotoxin, a compound in etoposide used as chemotherapy drug for treating cancer in the ...
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Podophyllotoxin possesses a large number of medical applications, as it inhibits replication of both cellular and viral DNA by binding necessary enzymes. It can additionally destabilize microtubules and prevent cell division. Because of these interactions it is considered an antimitotic drug. The sequential discovery of podophyllotoxin-group of drugs.
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FDA approved anticancer drugs etoposide, teniposide and etopophos were derived from the parent compound podophyllotoxin, which was originally extracted from mayapple plant as a curative for various diseases. Podophyllotoxin is an antimitotic. It acts by preventing viral wart cells from dividing and multiplying. Eventually all the wart cells die and new healthy cells grow in their place. For centuries, Native American tribes used the plant and its root for its medicinal, as well as poisonous, properties.
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Various uses of the plant included: Learn about Podophyllotoxin, its indications for treating warts, recommended dosage, potential side effects, and necessary precautions. Understand the contraindications and drug interactions associated with Podophyllotoxin. Podofilox, also called podophyllotoxin, is a purer and more stable form of podophyllin in which only the biologically active portion of the compound is present. Podophyllotoxin is a non-alkaloid toxic lignan extracted from roots and rhizomes of Podophyllum and Dysosma species. Podophyllotoxin was isolated in 1880s, and their structure was elucidated in 1950s (Nirmala et al., 2011). Podophyllotoxin is an organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent.
It is found in the roots and rhizomes of Podophyllum species and is used for the topical treatment of genital warts. Podophyllotoxin (PTOX) is a significant lignan in Linum album that is widely utilized as a precursor to produce excellent anticancer derivatives. Our previous study illustrated that exogenous phenylalanine (Phe) had a beneficial impact on the production of PTOX in L. album cell culture.