pemphigus vulgaris nikolsky sign - HEALTHY
Pemphigus vulgaris is a rare autoimmune disease that is characterised by painful blisters and erosions on the skin and mucous membranes, most commonly inside the mouth. It accounts for 70% of all pemphigus cases worldwide. Images below show mucosal lesions.
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Pemphigus. Authoritative facts from DermNet New Zealand. DermNet pages about pemphigus Benign familial pemphigus Brazilian pemphigus foliaceus Drug-induced pemphigus Endemic pemphigus foliaceus Familial benign pemphigus pathology IgA pemphigus Paraneoplastic pemphigus Paraneoplastic pemphigus pathology Pemphigus foliaceus Pemphigus foliaceus pathology Pemphigus vulgaris Pemphigus vulgaris ... What is benign familial pemphigus?
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Benign familial pemphigus is also known as Hailey–Hailey disease. It is a rare hereditary blistering skin disease first described by the Hailey brothers in 1939. Unrelated to pemphigus vulgaris, Hailey-Hailey disease is not an autoimmune condition and has a differing prognosis. Pemphigus vulgaris is a chronic vesiculobullous skin disorder characterised by autoantibodies against desmoglein 3, which is a component of the desmosome (an intracellular adhesion molecule). Disruption of keratinocyte adhesion leads to superficial blistering and erosion affecting the skin and/or mucous membranes.
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Histology of pemphigus vulgaris Early lesions of pemphigus vulgaris show ... Pemphigus vulgaris is a rare autoimmune condition that causes painful blistering on the skin and mucous membranes. These blisters commonly appear in the mouth and are prone to bursting easily, which ... An autoimmune blistering disease of the mucous membranes and skin, pemphigus vulgaris (PV) derives its name from the Greek word, pemphix, for blister. 1 PV is characteristically seen in older patients ...