leser trelat sign - HEALTHY
The sign of Leser-Trelat is considered to be a fairly rare paraneoplastic cutaneous marker of internal malignancy with the hallmark finding being an abrupt eruption of multiple seborrheic keratoses. What is the sign of Leser-Trélat? The sign of Leser-Trélat is a skin disorder characterised by the abrupt appearance of multiple seborrhoeic keratoses that rapidly increase in their size and number.
Context Explanation
It is caused by an associated cancer and often occurs with malignant acanthosis nigricans. The Leser–Trélat sign is the explosive onset of multiple seborrheic keratoses [1] (many pigmented skin lesions), [2][3] often with an inflammatory base. This can be a sign of internal malignancy as part of a paraneoplastic syndrome. She also reported the sudden onset of “itchy moles” on her back.
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Physical examination revealed multiple brown papules with a “stuck-on” appearance on her upper back, consistent with seborrheic keratoses (Figure 1), raising concern for the Leser-Trélat sign. The sign of Leser-Trélat, a rare finding, is the sudden eruption of multiple seborrheic keratoses caused by a malignancy. The sign of Leser-Trélat often occurs with malignant acanthosis... It was the sign of Leser-Trélat, the cutaneous whisper of something far graver beneath. The Leser-Trélat sign is a rare but critical dermatologic phenomenon—an abrupt eruption of seborrheic keratoses, sometimes accompanied by pruritus.
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The Sign of Leser-Trélat: A Fateful Encounter and the Silent Warning of ... The Leser-Trélat sign is a warning sign on the skin that may indicate the presence of cancer in the body. It causes sudden appearance of multiple harmless skin growths known as seborrheic keratoses. The Leser-Trélat sign is a relatively rare paraneoplastic cutaneous marker of internal malignancy characterized as the finding of multiple seborrheic keratoses that have abruptly erupted. The sign of Leser-Tre´lat is rare. It is defined as the sudden eruption of multiple seborrheic keratoses caused by a malignancy.
Because both seborrheic keratoses and cancer are common in the elderly, it is not always easy to tell from the literature or in any given patient if this sign is present. In fact, its validity has been questioned. The Leser-Trélat sign is a rare paraneoplastic cutaneous marker associated with internal malignancies characterized by the abrupt eruption of multiple seborrheic keratoses.