Bullous pemphigoid (BUL-us PEM-fih-goid) is a rare skin condition that causes large fluid-filled blisters. They often appear on the skin near creases, such as the upper thighs and armpits. Sometimes, people get a rash instead of blisters.

Context Explanation

The affected areas may be painful and are usually very itchy. Bullous pemphigoid is an autoimmune disease that causes blisters on your skin. Treatment includes corticosteroids or nonsteroidal medications. Epidermolysis bullosa is a group of inherited diseases in which epithelial adhesion protein defects lead to epithelial fragility and bullae formation.

Insight Material

Epidermolysis bullosa acquisita is a similar bullous disease thought to be autoimmune, but it is not inherited. The meaning of BULLOUS is resembling or characterized by bullae : vesicular. How to use bullous in a sentence. Bullous pemphigoid is an autoimmune disorder that occurs when the body's immune system attacks and destroys healthy body tissue by mistake. Specifically, the immune system attacks the proteins that attach the top layer of skin (epidermis) to the bottom layer of skin.

Final Conclusion

If you have blisters that come and go, itching all over your body, or other signs of bullous pemphigoid, it’s important to see a dermatologist. Left untreated, this disease can lead to a serious infection or other life-threatening medical condition. Autoimmune bullous disorders are a heterogeneous spectrum of skin disorders characterized by the production of autoantibodies against adhesion molecules of the skin. The 2 major groups of diseases are “pemphigus diseases” and “autoimmune bullous diseases of the pemphigoid type.” Bullous pemphigoid (a type of pemphigoid) is an autoimmune pruritic skin disease that typically occurs in people aged over 60, that may involve the formation of blisters (bullae) in the space between the epidermal and dermal skin layers.